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Dr. Samantha McLean

MTIF Fellow, Microbiology

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Mannix-Fisher, E., and McLean, S., (2021) The antimicrobial activity of silver acetate against Acinetobacter baumannii in a Galleria mellonella infection model. PeerJ 9:e11196 DOI 10.7717/peerj.11196

Varney, A.M., Smitten, K.l., Thomas J.A., and McLean, S. (2020) Transcriptomic Analysis of the Activity and Mechanism of Action of a Ruthenium(II)-Based Antimicrobial That Induces Minimal Evolution of Pathogen Resistance. ACS Pharmacology & Translational Science DOI: 10.1021/acsptsci.0c00159

Wareham, L.K., McLean, S., Begg, R., Rana, N., Ali, S., Kendall, J.J., Sanguinetti, G., Mann, B.E., and Poole, R.K. (2018) The Broad-Spectrum Antimicrobial Potential of [Mn(CO)4(S2CNMe(CH2CO2H))], a Water-Soluble CO-Releasing Molecule (CORM-401): Intracellular Accumulation, Transcriptomic and Statistical Analyses, and Membrane Polarization. Antioxidants and Redox Signalling 28(14), 1286-1308

McLean, S., Begg, R., Jesse, H.E., Mann, B.E., Sanguinetti, G., and Poole, R.K. (2013) Analysis of the bacterial response to Ru(CO)3Cl(glycinate) (CORM-3) and the inactivated compound identifies the role played by the ruthenium compound and reveals sulphur-containing species as a major target of CORM-3 action. Antioxidants and Redox Signalling 17, 1999-2012


IRep Publications


Areas of Expertise

  • Development of Novel Antimicrobials
  • Mechanism of Action Studies
  • Antimicrobial Activity Testing
  • Bespoke Models for Biofilm Formation
  • Bacterial Transcriptomic Analyses
  • Microbiology testing to recognised standards (BSI, ASTM, ISO etc.)
  • Bacterial Bioreactor studies under steady state
  • Biofilm Characterisation
  • In Vivo Toxicity and Infection Studies


Roles and Responsibilities

Dr Samantha McLean is a senior lecturer in microbiology, her research group focusses on the development and evaluation of new antimicrobial technologies that reduce microbial contamination of materials. Her group has expertise including classical microbiology, antimicrobial testing, transcriptomics, standards (BSI, ISO) and the design and use of bespoke models for real-world microbiology application. Samantha is also a member of the British Standards Institute panel working group (products and biofilms).

Other Team Members

Dr Adam Varney
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Becky Coxhill
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Prof John Hunt
Prof. John Hunt
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